NPJ Parkinson's Disease
Diabetes drug target genes show no clear Parkinson’s link in humans
A genetic analysis of 42,083 Parkinson’s cases and 457,090 controls found no significant link between selected diabetes drug targets and disease risk.A genetic analysis of 42,083 Parkinson’s cases and 457,090 controls found no significant link between selected diabetes drug targets and disease risk.
Mendelian randomizationParkinson's disease
Who was studiedPeople with Parkinson's disease and PD-free controls
What changedParkinson's disease risk and age at onset showed no clear association with genetic variation in diabetes drug targets
The catchDPP-4 genetic proxies failed the diabetes-risk validation check, weakening results for this drug class