Parkinson's disease diagnosis

1. Occupational pesticide exposure is associated with Parkinson's disease diagnosis in humans (OR 1.36, 95% CI 0.98–1.90; p=<0.12).

   “A trending, non-significant association between pesticide exposure and PD diagnosis was observed (Odds Ratio (95% CI) 1.36 (0.98 to 1.90) p=<0.12).”

   Humansn = 21,049

   Occupational Pesticide Exposure and Regional Brain Volume Differences in UK BioBank

   medRxiv·Dec 29, 2025Preprint

More on Occupational pesticide exposure

1. MDS research criteria-based probability of prodromal Parkinson's disease predicts Parkinson's disease diagnosis in humans (Probability ≥ 0.8 compared with probability < 0.2) (RR 21.96, 95% CI 11.17–43.17).

   “The risk of PD was 21-fold higher in men with a probability of prodromal PD ≥ 0.8 compared with those with a probability < 0.2”

   HumansProbability ≥ 0.8 compared with probability < 0.2males

   Identifying Individuals in the Prodromal Phase of Parkinson's Disease: A Prospective Cohort Study

   Annals of neurology·Dec 19, 2024

More on MDS research criteria-based probability of prodromal Parkinson's disease

1. Co-occurrence of constipation, probable REM sleep behavior disorder, and hyposmia predicts Parkinson's disease diagnosis in humans (Compared with men without constipation, probable REM sleep behavior disorder, and hyposmia) (RR 23.35, 95% CI 10.62–51.33).

   “Men with constipation, pRBD, and hyposmia had a 23-fold higher risk of receiving a PD diagnosis in the subsequent 3 years”

   HumansCompared with men without constipation, probable REM sleep behavior disorder, and hyposmia3 yearsmales

   Identifying Individuals in the Prodromal Phase of Parkinson's Disease: A Prospective Cohort Study

   Annals of neurology·Dec 19, 2024

More on Co-occurrence of constipation, probable REM sleep behavior disorder, and hyposmia

1. speech classifiers predict Parkinson's disease diagnosis in silico (Classification using speech recordings) (AUC 0.72 ten years before diagnosis, 0.75 five years before diagnosis, and 0.93 post-diagnosis).

   “the best classifiers achieving AUCs of 0.72 and 0.75 for data collected ten and five years before diagnosis, respectively, and 0.93 post-diagnosis.”

   In silicoClassification using speech recordingsTen and five years before diagnosis and post-diagnosis

   Unveiling early signs of Parkinson's disease via a longitudinal analysis of celebrity speech recordings

   NPJ Parkinson's disease·Oct 27, 2024