AgingResearch.NewsJoin free

Microscopic colitis

There are 2 papers on microscopic colitis in aging research: 2 observational studies in people.

Disease

2 papers study it5 findings

See all 2 papers on microscopic colitis

“The estimated 12-month risk difference was 0.04% (95% CI, 0.03% to 0.05%) for selective serotonin receptor inhibitors (SSRIs) versus mirtazapine.”
Medications and Risk for Microscopic Colitis: A Nationwide Study of Older Adults in SwedenAnnals of internal medicine2025doi:10.7326/annals-25-00268
  • Humans2

Interventions

2

Nsaids

no changein humans1

1 study

  1. Nsaids were not clearly linked with microscopic colitis in humans (target trial emulation) (close to null).

    “nonsteroidal anti-inflammatory drug initiation versus noninitiation, proton-pump inhibitor initiation versus noninitiation, and statin initiation versus noninitiation.”

    Humanstarget trial emulation12 months

    Medications and Risk for Microscopic Colitis: A Nationwide Study of Older Adults in Sweden

    Annals of internal medicine

More on Nsaids

Angiotensin-converting enzyme inhibitors

no changein humans1

1 study

  1. Angiotensin-converting enzyme inhibitors were not clearly linked with microscopic colitis in humans (target trial emulation) (close to null).

    “Estimated 12-month risk differences were close to null under angiotensin-converting enzyme versus calcium-channel blocker (CCB) initiation, angiotensin-receptor blocker versus CCB initiation”

    Humanstarget trial emulation12 months

    Medications and Risk for Microscopic Colitis: A Nationwide Study of Older Adults in Sweden

    Annals of internal medicine

More on Angiotensin-converting enzyme inhibitors

Associations

3

Preexisting dementia

downin humans1

1 study

  1. Microscopic colitis is associated with preexisting dementia in humans (Compared with population-based comparators; matched case-control analysis) (aOR 0.73, 95% CI 0.65–0.82).

    “Prior dementia was less prevalent in MC (adjusted odds ratio [aOR]: 0.73; 95% CI: 0.65-0.82).”

    HumansCompared with population-based comparators; matched case-control analysis

    Microscopic colitis is associated with an increased risk of dementia in a Swedish population

    Journal of internal medicine

More on Preexisting dementia

Dementia

upin humans1

1 study

  1. Microscopic colitis is associated with dementia in humans (Compared with population-based comparators) (19% higher risk; aHR 1.19, 95% CI 1.07–1.32).

    “During the first 5 years since biopsy, MC was associated with a 19% higher dementia risk”

    HumansCompared with population-based comparatorsFirst 5 years since biopsy

    Microscopic colitis is associated with an increased risk of dementia in a Swedish population

    Journal of internal medicine

More on Dementia

Selective serotonin reuptake inhibitors

upin humans1

1 study

  1. Selective serotonin reuptake inhibitors are linked with a higher risk of microscopic colitis in humans (versus mirtazapine) (RD 0.04% (95% CI, 0.03% to 0.05%)).

    “The estimated 12-month risk difference was 0.04% (95% CI, 0.03% to 0.05%) for selective serotonin receptor inhibitors (SSRIs) versus mirtazapine.”

    Humansversus mirtazapine12 months

    Medications and Risk for Microscopic Colitis: A Nationwide Study of Older Adults in Sweden

    Annals of internal medicine

More on Selective serotonin reuptake inhibitors

Trial sponsors

Latest

Related