Ischemic optic neuropathy

1. Semaglutide is associated with ischemic optic neuropathy in humans (ROR 4.42, 95% CI 1.41-13.87).

   “Additional notable safety signals included optic ischemic neuropathy with semaglutide (ROR = 4.42, 95% CI = 1.41-13.87)”

   HumansFAERS safety signal; reporting odds, not incidence

   Indication-specific adverse event profiles of semaglutide and liraglutide: a FAERS disproportionality analysis

   Frontiers in pharmacology·29 Sep 2026

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1. GLP-1 receptor agonists raise the risk of ischemic optic neuropathy in humans (RR 1.25, 95% CI 1.05-1.48).

   “NAION risk was slightly higher in the GLP Cohort (293 patients or 0.08%) vs the No GLP Cohort (234 patients or 0.06%) (RR = 1.25, 95% CI: 1.05-1.48, p = 0.011).”

   Humanstype 2 diabetes mellitus5-year

   OR08-07 Real-World Evidence on GLP-1 Analogues: Insights into NAION Risk in Type 2 Diabetes Mellitus Patients

   ENDO 2025 abstract·22 Oct 2025

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