Invasive prostate cancer

1. TP53 protects against invasive prostate cancer in mice.

   “combined inactivation of Pten and Trp53 elicits invasive prostate cancer as early as 2 weeks after puberty and is invariably lethal by 7 months of age”

   Animalsin Pten-deficient tumours

   Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

   Nature·4 Aug 2005

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