Incident advanced cardiovascular-kidney-metabolic syndrome

1. TyG-CVAI is associated with incident advanced cardiovascular-kidney-metabolic syndrome in humans (HR 1.290 per 1-SD increase, 95% CI 1.143–1.456; P < 0.001).

   “In the fully adjusted model, TyG-CVAI demonstrated the largest effect size (per 1-SD increase: HR = 1.290, 95% CI 1.143–1.456, P < 0.001).”

   HumansFree of advanced cardiovascular-kidney-metabolic syndrome at baseline; fully adjusted modelper 1-SD increase5 yearsn = 2,072

   Triglyceride-glucose-Chinese visceral adiposity index (TyG-CVAI) outperforms other TyG-derived indices in predicting 5-year advanced cardiovascular-kidney-metabolic syndrome: a prospective community-based cohort and machine learning study in China

   Cardiovascular diabetology·Oct 16, 2026

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