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Immune checkpoint inhibitor myocarditis

There are 2 papers on immune checkpoint inhibitor myocarditis in aging research: 1 observational study in people, 1 review. The newest story, Nov 12, 2026: “Immune signaling linked to cancer-drug heart inflammation”.

Disease

2 papers study it2 more mention it3 findings

2 new papers in 30 daysSee all 4 papers on immune checkpoint inhibitor myocarditis

“Top features associated with ICI myocarditis included IL13, CXCL10, PDGFA, CCL13, CCL17 and KITlg.”
Cytokine Signatures of Immune Checkpoint Inhibitor Myocarditis and the Modifying Role of Clonal Hematopoiesis: A Machine-Learning and Multi-Omics StudymedRxiv2026doi:10.64898/2026.11.11.26367634
  • Humans1

Associations

3

JAK–STAT signaling

mixedin humans1

1 study

  1. JAK–STAT signaling is associated with immune checkpoint inhibitor myocarditis in humans.

    “Across cohorts, JAK STAT signaling emerges as a convergent and potentially actionable axis in ICI myocarditis that is further amplified in CHIP carriers”

    Humansperipheral blood

    Immune signaling linked to cancer-drug heart inflammation

    medRxivPreprint

More on JAK–STAT signaling

IL-13, CXCL10, PDGF-A, CCL13, CCL17, and KIT ligand

mixedin humans1

1 study

  1. IL-13, CXCL10, PDGF-A, CCL13, CCL17, and KIT ligand is associated with immune checkpoint inhibitor myocarditis in humans (patients on immune checkpoint inhibitors).

    “Top features associated with ICI myocarditis included IL13, CXCL10, PDGFA, CCL13, CCL17 and KITlg.”

    Humanspatients on immune checkpoint inhibitors

    Immune signaling linked to cancer-drug heart inflammation

    medRxivPreprint

More on IL-13, CXCL10, PDGF-A, CCL13, CCL17, and KIT ligand

Clonal hematopoiesis of indeterminate potential

upin humans1

1 study

  1. Clonal hematopoiesis of indeterminate potential is associated with immune checkpoint inhibitor myocarditis in humans (reported in separate observational studies).

    “Separate studies associate CHIP with ICI myocarditis and with severe cytokine release syndrome”

    Reviewreported in separate observational studies

    Clonal hematopoiesis of indeterminate potential and cancer immunotherapy: a host-intrinsic immune-inflammatory modifier of treatment efficacy and toxicity

    Frontiers in oncology

More on Clonal hematopoiesis of indeterminate potential

Latest

Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 1Oct 2026: 0Nov 2026: 23 papers in 12 months
medRxiv

Immune signaling linked to cancer-drug heart inflammation

An observational study enrolled 236 patients in cancer-related heart care, including 88 taking immune checkpoint inhibitors, and identified an inflammation-linked…An observational study enrolled 236 patients in cancer-related heart care, including 88 taking immune checkpoint inhibitors, and identified an inflammation-linked signaling pathway.

Preprint: cohort studyJAK–STAT signaling
Paper

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