Hypoplastic left heart syndrome

1. Hypoplastic left heart syndrome induces cellular senescence in humans.

   “We show that HLHS cardiomyocytes, both within the heart and when derived from induced pluripotent stem cells, are intrinsically senescent.”

   Humanshypoplastic left heart syndromeheart

   Ventricular assist device unloading reverses microvascular senescence in single ventricle disease

   Nature cardiovascular research·4 Mar 2026

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