Exocrine pancreatic insufficiency

1. GLP-1 receptor agonists are linked with a lower risk of exocrine pancreatic insufficiency in patients with diabetes and chronic pancreatitis vs SGLT2 inhibitors (HR 0.473, 95% CI 0.355–0.630).

   “GLP-1 RA use was also associated with lower recorded risks of exocrine pancreatic insufficiency (2.4% vs 4.7%; RR, 0.495; 95% CI, 0.374–0.657; HR, 0.473; 95% CI, 0.355–0.630)”

   Humansin patients with diabetes and chronic pancreatitis vs SGLT2 inhibitorspancreasday 1 through day 1825n = 3,373

   GLP-1 Receptor Agonists Versus SGLT2 Inhibitors in Diabetes and Chronic Pancreatitis: A Real World Cohort Study of Pancreatic Outcomes

   Research Square·Jul 30, 2026Preprint

More on GLP-1 receptor agonists

1. Exocrine pancreatic insufficiency is linked with a higher risk of diabetes mellitus in humans (21.2% vs 11.4%).

   “EPI patients without DM had a greater diabetes incidence rate than obese patients without DM but no EPI from the same practice population over the same observation period (21.2% vs 11.4%).”

   Humans3 years

   MON-585 Exocrine Pancreatic Insufficiency Is a Risk Factor for Future Development of Diabetes Mellitus

   ENDO 2025 abstract·Oct 22, 2025

More on Diabetes mellitus

1. Exocrine pancreatic insufficiency is linked with a higher risk of osteoporosis in chronic pancreatitis patients (OR: 8.1, P = .003).

   “Factors independently associated with osteopenia/osteoporosis included female gender (OR: 7.8, P = .004), severe EPI (OR: 8.1, P = .003), and sarcopenia (OR: 5, P = .037).”

   Humansin chronic pancreatitis patientsn = 83

   Clinical Features and Prevalence of Osteosarcopenia in Chronic Pancreatitis

   The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology·May 5, 2025

More on Osteoporosis

1. Exocrine pancreatic insufficiency is linked with a higher risk of sarcopenia in chronic pancreatitis patients (OR: 4.2, P = .043).

   “Factors associated with sarcopenia included male gender (OR: 4.9, P = .044), severe EPI (OR: 4.2, P = .043), smoking (OR: 4.6, P = .040), and zinc deficiency (OR: 2.2, P = .029).”

   Humansin chronic pancreatitis patientsn = 83

   Clinical Features and Prevalence of Osteosarcopenia in Chronic Pancreatitis

   The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology·May 5, 2025

More on Sarcopenia