Cutaneous leishmaniasis
1 paper1 finding
- Humans1
Effects
1Cell killing (cytotoxicity)
upin human cells1
1 study
Cell killing (cytotoxicity)
upin human cells1
Cutaneous leishmaniasis increases cell killing (cytotoxicity) in human cells.
“we identified accumulation of CD4+ granzyme B producing T cells with increased cytotoxic capacity in CL lesions.”
Cellshuman cutaneous leishmaniasis lesionsskin
Frontiers in immunologyOct 21, 2024
Trial sponsors
1 trialPhase 3136 people
Latest
Frontiers in Immunology
Lesional senescent CD4⁺ T cells mediate bystander cytolysis and contribute to the skin pathology of human cutaneous leishmaniasis
Cross-sectional study in peopleCellular senescence
Clinical and Experimental Immunology
Senescence-related genes are associated with the immunopathology signature of American tegumentary leishmaniasis lesions and may predict progression to mucosal leishmaniasis
Computational studyBiomarkers
Clinical and Experimental Immunology
NKG2C+CD57+ natural killer cells with senescent features are induced during cutaneous leishmaniasis and accumulate in patients with lesional healing impairment
Study in peopleMechanisms