Cancer diagnosis

1. Cancer diagnosis is linked with worse cognitive function in humans (incident cancer diagnosis in White participants) (-0.065 vs. 0.024 SD, P<0.0001).

   “An incident cancer diagnosis was associated with an acute memory drop in White, but not Black participants (-0.065 vs. 0.024; P<0.0001).”

   Humansincident cancer diagnosis in White participantsn = 14,235

   Does a Cancer Diagnosis in Mid-to-Later Life Modify Racial Disparities in Memory Aging?

   Alzheimer disease and associated disorders·Feb 4, 2022

1. Cancer diagnosis is linked with higher physical frailty in humans (rate of increase in physical frailty over time after diagnosis).

   “In linear mixed-effects models, the rate of increase in physical frailty over time was statistically significantly higher after cancer diagnosis.”

   Humansrate of increase in physical frailty over time after diagnosisfemalesn = 7,257

   Association of Prediagnostic Frailty, Change in Frailty Status, and Mortality After Cancer Diagnosis in the Women's Health Initiative

   JAMA network open·Sep 1, 2020

1. Cancer diagnosis is linked with lower memory function in humans (short-term, compared with memory before diagnosis) (-0.058 SD units (95% CI, -0.084 to -0.032)).

   “A new cancer diagnosis was associated with a short-term decline in memory of -0.058 (95% CI, -0.084 to -0.032) SD units compared with memory before diagnosis.”

   Humansshort-term, compared with memory before diagnosis

   Rate of Memory Change Before and After Cancer Diagnosis

   JAMA network open·Jun 5, 2019

1. Cancer diagnosis is linked with lower memory decline in the decade before a cancer diagnosis (10.5% (95% CI, 6.2%-14.9%)).

   “The rate of memory decline in the decade before a cancer diagnosis was 10.5% (95% CI, 6.2%-14.9%), which was slower than memory decline in similarly aged cancer-free individuals.”

   Humansin the decade before a cancer diagnosis

   Rate of Memory Change Before and After Cancer Diagnosis

   JAMA network open·Jun 5, 2019

1. Cancer diagnosis was not clearly linked with symptom burden in humans.

   “Symptoms cannot be attributed solely to a diagnosis of cancer.”

   Humansn = 381

   High Symptom Burden and Low Functional Status in the Setting of Multimorbidity

   Journal of the American Geriatrics Society·Aug 30, 2017

1. Cancer diagnosis is linked with higher chronic condition clusters in humans among older cancer survivors with two or more chronic conditions (cardiovascular 6.1% to 7.7%, musculoskeletal 28.2% to 29.3%, metabolic 14.9% to 17.6%).

   “Cluster prevalence increases from pre- to post-cancer diagnosis”

   Humansamong older cancer survivors with two or more chronic conditionsn = 5,991

   Chronic condition clusters and functional impairment in older cancer survivors: a population-based study

   Journal of cancer survivorship : research and practice·May 27, 2016

More on Chronic condition clusters

1. Artificial intelligence-guided navigation is associated with cancer diagnosis in humans (Patients with new high-risk incidental findings navigated to multidisciplinary care) (67 cancer diagnoses; 15% incidence among navigated patients).

   “After additional work up, 67 patients were ultimately diagnosed with cancer including 14 (21%) liver, 45 (67%) lung, and 8 (12%) pancreatic cancers.”

   HumansPatients with new high-risk incidental findings navigated to multidisciplinary caren = 445

   Artificial Intelligence Guided Navigation of High-Risk Incidental Findings on Imaging Studies Leads to Cancer Diagnoses

   The Journal of surgical research·Nov 5, 2026

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1. Galleri MCED test predicts cancer diagnosis in humans (positive MCED test result) (78.6% confirmed cancer diagnosis (21.4% false positives)).

   “Of the 14 patients with a positive MCED test, 78.6% had a confirmed cancer diagnosis, whereas 21.4% were false positives.”

   Humanspositive MCED test result64.3% malesn = 14

   Diagnostic Outcomes among Patients with Positive Multi-Cancer Early Detection Test Results

   Cancer research communications·Feb 21, 2026

More on Galleri MCED test

1. FreeSV predicts cancer diagnosis in humans across cancer types (AUC 0.81-0.92).

   “the FreeSV model achieved area under the ROC curves (AUCs) between 0.81-0.92 across cancer types”

   Humansacross cancer typesplasma

   Cancer-Like Fragmentomic Characteristics of Somatic Variants in Cell-Free DNA

   Advanced science (Weinheim, Baden-Wurttemberg, Germany)·Jan 22, 2026

More on FreeSV

1. Cancer diagnosis is associated with memory function in humans (immediately before diagnosis) (0.096 SD units higher (95% CI, 0.060-0.133)).

   “For individuals diagnosed at 75 years of age, mean memory function immediately before diagnosis was 0.096 SD units (95% CI, 0.060-0.133 SD units) higher compared with that among similarly aged cancer-free individuals.”

   Humansimmediately before diagnosis

   Rate of Memory Change Before and After Cancer Diagnosis

   JAMA network open·Jun 5, 2019