Brain amyloidosis

1. Aβ42/Aβ40 predicts brain amyloidosis in humans (AUC 0.86 (95% CI 0.79-0.92)).

   “The receiver operating characteristic area under the curve of CSF Aβ42/Aβ40 status with the plasma biomarkers was as follows: Aβ42/Aβ40, 0.86 (95% CI 0.79-0.92)”

   Humansplasman = 152

   Effect of Race on Prediction of Brain Amyloidosis by Plasma Aβ42/Aβ40, Phosphorylated Tau, and Neurofilament Light

   Neurology·21 Apr 2022

More on Aβ42/Aβ40

1. race is associated with brain amyloidosis in humans (22% vs 43% positive; p = 0.003).

   “AA were less likely than NHW participants to have brain amyloidosis by CSF Aβ42/Aβ40 (22% vs 43% positive; p = 0.003).”

   Humansmatched for age, APOE ε4 carrier status, and cognitive statusbrainn = 152

   Effect of Race on Prediction of Brain Amyloidosis by Plasma Aβ42/Aβ40, Phosphorylated Tau, and Neurofilament Light

   Neurology·21 Apr 2022