Amnestic objective subtle cognitive decline

There is 1 paper on amnestic objective subtle cognitive decline in aging research: 1 observational study in people. The newest story, Nov 2, 2026: “Subtle memory decline linked to Alzheimer’s disease markers”.

Disease

1 paper studies it4 findings

See all 1

“Amnestic obj-SCD was identified in 10% of the sample, associated with greater AD pathology (higher plasma p-tau217, CSF p-tau181/Aβ42, global Aβ PET, medial temporal tau PET)”
Multimodal biomarker characterization of amnestic objective subtle cognitive decline in aging and preclinical Alzheimer's diseaseThe journal of prevention of Alzheimer's disease2026doi:10.1016/j.tjpad.2026.100612
  • Humans1

Associations

4

GFAP

upin humans1

1 study
  1. Amnestic objective subtle cognitive decline is associated with GFAP in humans (cognitively unimpaired individuals).

    “inflammation (higher plasma and CSF GFAP, longitudinal GMv increases in neocortical brain regions)”

    Humanscognitively unimpaired individuals3-year follow-upn = 350

    Subtle memory decline linked to Alzheimer’s disease markers

    The journal of prevention of Alzheimer's disease

More on GFAP

Gray matter volume

downin humans1

1 study
  1. Amnestic objective subtle cognitive decline is associated with gray matter volume in humans (cognitively unimpaired individuals).

    “reduced GMv in cingulate cortex, longitudinal GMv reductions in hippocampus”

    Humanscognitively unimpaired individuals3-year follow-upn = 350

    Subtle memory decline linked to Alzheimer’s disease markers

    The journal of prevention of Alzheimer's disease

More on Gray matter volume

NfL

upin humans1

1 study
  1. Amnestic objective subtle cognitive decline is associated with NfL in humans (cognitively unimpaired individuals).

    “neurodegeneration (higher plasma and CSF NfL, reduced GMv in cingulate cortex, longitudinal GMv reductions in hippocampus)”

    Humanscognitively unimpaired individuals3-year follow-upn = 350

    Subtle memory decline linked to Alzheimer’s disease markers

    The journal of prevention of Alzheimer's disease

More on NfL

Plasma P-TAU217

upin humans1

1 study
  1. Amnestic objective subtle cognitive decline is associated with plasma P-TAU217 in humans (cognitively unimpaired individuals).

    “Amnestic obj-SCD was identified in 10% of the sample, associated with greater AD pathology (higher plasma p-tau217, CSF p-tau181/Aβ42, global Aβ PET, medial temporal tau PET)”

    Humanscognitively unimpaired individuals3-year follow-upn = 350

    Subtle memory decline linked to Alzheimer’s disease markers

    The journal of prevention of Alzheimer's disease

More on Plasma P-TAU217

Latest

Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 1Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 0Nov 2026: 01 paper in 12 months
The Journal of Prevention of Alzheimer's Disease

Subtle memory decline linked to Alzheimer’s disease markers

Over three years, 10% of 350 adults without cognitive impairment showed subtle memory decline, linked to higher Alzheimer’s markers than in those with stable memory.Over three years, 10% of 350 adults without cognitive impairment showed subtle memory decline, linked to higher Alzheimer’s markers than in those with stable memory.