α-synuclein-related neurodegenerative disease

1. Isolated REM sleep behavior disorder is associated with α-synuclein-related neurodegenerative disease in humans (isolated REM sleep behavior disorder).

   “isolated RBD (iRBD) is strongly associated with future development of α-synuclein-related neurodegenerative diseases”

   Reviewisolated REM sleep behavior disorder

   Rapid Eye Movement Sleep Behavior Disorder as a Prodromal Manifestation of Alpha-Synucleinopathies

   Cureus·Oct 7, 2026

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1. Isolated rapid eye movement sleep behavior disorder predicts α-synuclein-related neurodegenerative disease in later life (>80%).

   “It is the strongest known predictor of α-synuclein-related neurodegenerative disease (αNDD), such that >80% of people with iRBD will eventually develop Parkinson's disease, dementia with Lewy bodies, or multiple system atrophy”

   Reviewin later life

   Isolated rapid eye movement sleep behaviour disorder (iRBD) in the Island Study Linking Ageing and Neurodegenerative Disease (ISLAND) Sleep Study: protocol and baseline characteristics

   Journal of sleep research·Nov 28, 2023

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