There are 3 papers on adult obesity in aging research: 3 observational studies in people. The newest story, Oct 5, 2026: “Childhood housing aid linked to lower diabetes and hypertension risk”.
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“After adjustment, early-life undernutrition was associated with higher odds of adult obesity (OR = 2.46; 95% CI: 1.75–3.45).”
NR5A1
no changein humans1OR 1.019
NR5A1 was not clearly linked with adult obesity in humans (Carriers of rare deleterious missense NR5A1/SF-1 variants) (OR = 1.019, 95% CI: 0.955, 1.088).
“but not men (OR = 1.019, [95% CI: 0.955, 1.088], P = .57, N = 168)”
HumansCarriers of rare deleterious missense NR5A1/SF-1 variantsmalesn = 168
Population-Based Study of Rare Coding Variants in NR5A1/SF-1
Journal of the Endocrine Society
Living with a partner
upin humans1OR 2.12
Living with a partner is associated with adult obesity in humans (Indigenous women in Alagoas, Brazil; adjusted association) (OR = 2.12; 95% CI: 1.47–3.45).
“living with a partner (OR = 2.12; 95% CI: 1.47–3.45) were independently associated with obesity.”
HumansIndigenous women in Alagoas, Brazil; adjusted associationfemalesn = 813
Research SquarePreprint
Participation in the labor market
upin humans1OR 1.42
Participation in the labor market is associated with adult obesity in humans (Indigenous women in Alagoas, Brazil; adjusted association) (OR = 1.42; 95% CI: 1.03–1.96).
“participation in the labor market (OR = 1.42; 95% CI: 1.03–1.96) and living with a partner (OR = 2.12; 95% CI: 1.47–3.45) were independently associated with obesity.”
HumansIndigenous women in Alagoas, Brazil; adjusted associationfemalesn = 813
Research SquarePreprint
Early-life undernutrition
upin humans1OR 2.46
Early-life undernutrition is associated with adult obesity in humans (Indigenous women in Alagoas, Brazil; adjusted association; exposure defined by HHI > 1.028) (OR = 2.46; 95% CI: 1.75–3.45).
“After adjustment, early-life undernutrition was associated with higher odds of adult obesity (OR = 2.46; 95% CI: 1.75–3.45).”
HumansIndigenous women in Alagoas, Brazil; adjusted association; exposure defined by HHI > 1.028femalesn = 813
Research SquarePreprint
NR5A1
upin humans1OR 1.061
NR5A1 is associated with adult obesity in humans (Carriers of rare deleterious missense NR5A1/SF-1 variants) (OR = 1.061, 95% CI: 1.003, 1.104).
“Carriers also had a higher risk of adult obesity (OR = 1.061, [95% CI: 1.003, 1.104], N = 344, P = .015)”
HumansCarriers of rare deleterious missense NR5A1/SF-1 variantsn = 344
Population-Based Study of Rare Coding Variants in NR5A1/SF-1
Journal of the Endocrine Society
Company1 trialPhase 2151 people
Five or more years of childhood assistance was associated with 69 percent lower adult diabetes risk and 39 percent lower hypertension risk than no childhood assistance.Five or more years of childhood assistance was associated with 69 percent lower adult diabetes risk and 39 percent lower hypertension risk than no childhood assistance.