bioRxiv
Estrogen loss reduced acetaminophen liver injury in mice
Female mice given acetaminophen six months after ovary removal showed altered liver fats and sustained activity of a stress-defense protein.Female mice given acetaminophen six months after ovary removal showed altered liver fats and sustained activity of a stress-defense protein.
Preprint: mouse studyMechanisms
Who was studiedFemale C57BL/6JOlaHsd mice, six months, against sham-operated mice
What changedMice with long-term estrogen loss were less susceptible to acetaminophen liver injury than sham-operated mice
The catchOnly overdose challenges were used, at 360 or 600 mg/kg acetaminophen
