VACS-CCI

1. VACS-CCI is linked with higher physiological age in humans (overall) (4.6-3.1 years).

   “Among 65-year-old males-females, "physiological age" exceeded chronological age by 4.6-3.1 years overall; 8.6-7.8 years for diabetes; and 13.5-11.6 years for HIV.”

   Humansoverall

   Health-record score predicts survival better than age alone

   EBioMedicine·Jul 16, 2026

More on Physiological age

1. VACS-CCI predicts mortality in humans among patients in care within US Veterans Health Administration (0.81 vs. 0.74).

   “Among 6.6 million (51.4% ≥ 65 years; 25.2% with diabetes; 0.5% with HIV) VACS-CCI improved discrimination over age (Overall C-statistic: 0.81 vs. 0.74; Brier Score 0.239 vs. 0.262).”

   Humansamong patients in care within US Veterans Health Administration10 years

   Health-record score predicts survival better than age alone

   EBioMedicine·Jul 16, 2026

1. VACS-CCI predicts non-prostate cancer mortality in humans (nonmetastatic prostate cancer) (C statistic 0.75, 95% CI 0.74-0.75).

   “Compared with CCI and age alone (C statistic 0.67, 95% confidence interval [CI] 0.67-0.68), VACS-CCI demonstrated improved validated discrimination (C statistic 0.75, 95% CI 0.74-0.75 for non-PCM).”

   Humansnonmetastatic prostate cancermalesn = 107,370

   Adaption and National Validation of a Tool for Predicting Mortality from Other Causes Among Men with Nonmetastatic Prostate Cancer

   European urology oncology·Jan 3, 2024