Urolithin C

Biomarker

1 paper1 finding

Human trial1

Associations

Cortical thickness

upin humans1

1 study

Urolithin C is associated with cortical thickness in humans (β = 0.015 [95% CI, <0.001-0.029] per 1-SD).
“urolithin C (β = 0.015 [95% CI, <0.001-0.029] per 1-SD)”
HumansCognitively healthy participants allocated to the walnut diet; association with changes in urinary urolithin C.cerebral cortex2 yearsn = 55
Gut metabolites linked to preserved brain thickness in older adults
Food & function7 Oct 2026

Latest

1 in 12 months

Food & Function7 Oct

Gut metabolites linked to preserved brain thickness in older adults

In a 104-person trial sub-study, rising levels of gut-produced urolithins tracked with preserved cortical thickness over two years in 55 older adults eating walnuts.In a 104-person trial sub-study, rising levels of gut-produced urolithins tracked with preserved cortical thickness over two years in 55 older adults eating walnuts.

Cohort study of 104 peopleInterventions

Paper

Journal of Agricultural and Food Chemistry5 Jun

Urolithins are the main urinary microbial-derived phenolic metabolites discriminating a moderate consumption of nuts in free-living subjects with diagnosed metabolic syndrome

Randomised trial in peopleMetabolic syndrome