Unified ensemble transcriptomic aging clock

Unified ensemble transcriptomic aging clock predicts age prediction performance in silico (R2 = 0.854; MAE = 4.26 years).

“the unified ensemble clock achieved R 2 = 0.854 and MAE = 4.26 years—while uniquely providing calibrated confidence intervals.”

In silicoARCHS428 tissuesn = 57,584

Guided multi-agent AI invents highly accurate, uncertainty-aware transcriptomic aging clocks

bioRxiv (Cold Spring Harbor Laboratory)·12 Sep 2025Preprint