Ubiquitinated insoluble proteins

Old age increases ubiquitinated insoluble proteins in rats (1.22 ± 0.06 vs. 1.02 ± 0.06, P < 0.05).

“compromised proteostasis as evidenced by accumulation of ubiquitinated insoluble proteins (1.02 ± 0.06 vs. 1.22 ± 0.06, P < 0.05).”

Animalsreloading after 14 days of hindlimb unloadingskeletal muscle

Impaired proteostatic mechanisms other than decreased protein synthesis limit old skeletal muscle recovery after disuse atrophy

Journal of cachexia, sarcopenia and muscle·Jul 14, 2023