bioRxiv
Gene variants shape antioxidant defenses in aging mouse brains
Experiments in mice carrying human ApoE4 found lower antioxidant protein levels in youth and accumulating products of fat oxidation with age.Experiments in mice carrying human ApoE4 found lower antioxidant protein levels in youth and accumulating products of fat oxidation with age.
Preprint: mouse studyMechanisms
Who was studiedMice carrying human versions of APOE
What changedYoung humanized ApoE4 mice had lower antioxidant protein abundance before detectable oxidative damage
The catchAntioxidant defenses were measured; brain degeneration was not measured