Total normalized muscle volume

1. Total normalized muscle volume has no effect on brain age gap in humans.

   “No statistically significant links were noted with TNMV, VAT, SAT or and BAG.”

   Humansn = 1,164

   Higher Muscle Volume is Inversely Related to Chronological and Brain Age While Increased Visceral to Muscle Fat Ratio is Positively Related to Chronological and Brain Age · AAIC 2025 abstract · 8 Jan 2026

2. Total normalized muscle volume has no effect on brain age gap in humans.

   “No statistically significant links were noted with TNMV, VAT, SAT or and BAG.”

   Humansbrainn = 1,164

   Higher Muscle Volume is Inversely Related to Chronological and Brain Age While Increased Visceral to Muscle Fat Ratio is Positively Related to Chronological and Brain Age · AAIC 2025 abstract · 23 Dec 2025

Brain age gap →

1. Total normalized muscle volume is associated with brain age in humans (rp = -0.2497, p = 2.65e-16).

   “Higher TNMV was related to both decreased chronological age (rp=-0.2579, p = 2.524e-17) and brain age (rp =-0.2497, p = 2.65e-16).”

   Humansadjusted for sexn = 1,164

   Higher Muscle Volume is Inversely Related to Chronological and Brain Age While Increased Visceral to Muscle Fat Ratio is Positively Related to Chronological and Brain Age · AAIC 2025 abstract · 8 Jan 2026

2. Total normalized muscle volume is associated with brain age in humans (rp = -0.2497, p = 2.65e-16).

   “Higher TNMV was related to both decreased chronological age (rp=-0.2579, p = 2.524e-17) and brain age (rp =-0.2497, p = 2.65e-16).”

   Humansadjusted for sexbrainn = 1,164

   Higher Muscle Volume is Inversely Related to Chronological and Brain Age While Increased Visceral to Muscle Fat Ratio is Positively Related to Chronological and Brain Age · AAIC 2025 abstract · 23 Dec 2025

Brain age →