Total lean mass z-score

1. Trevogrumab increases total lean mass z-score in humans.

   “Statistical significance (CFB vs semaglutide alone) was met for TLM and TFM z-scores for all trevogrumab groups with and without garetosmab”

   Human trialwith or without garetosmab, on top of semaglutideweek 26n = 599

   Population-Normed Z-scores for Body Composition Enhance Sensitivity and Effect Size: Analysis of a Phase 2 RCT Testing Anti-GDF8 and Anti-Activin A on Top of Semaglutide (COURAGE)

   ADA Scientific Sessions 2026 abstract·5 Jun 2026

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