Tissue nicotinamide

1 paper studies it5 more mention it1 finding

Animals1

Upstream

1

CD38

upin mice1

1 study

CD38 increases tissue nicotinamide in mice.
“CD38 activity on endothelial and immune cells is the major contributor to tissue steady-state levels of NAM in tissues like spleen and heart.”
Animalsstudied using tissue-specific CD38-floxed miceendothelial and immune cells; spleen and heart
Endogenous metabolism in endothelial and immune cells generates most of the tissue vitamin B3 (nicotinamide)
iScienceOct 23, 2022

Latest

1 paper in 12 months

Ecotoxicology and Environmental SafetyFeb 1

Nicotinamide mononucleotide rescues perinatal arsenic-induced autism-like behaviours via modulation of NAD+ metabolism in mice

Experiments in miceNicotinamide mononucleotide

Scientific ReportsFeb 11

Meta-analysis of NAD(P)(H) quantification results exhibits variability across mammalian tissues

Meta-analysisNAD+

iScienceOct 23

Endogenous metabolism in endothelial and immune cells generates most of the tissue vitamin B3 (nicotinamide)

Experiments in miceNAD+ metabolism

Molecular & Cellular ProteomicsAug 6

Quantitative Acetylomics Reveals Dynamics of Protein Lysine Acetylation in Mouse Livers During Aging and Upon the Treatment of Nicotinamide Mononucleotide

Experiments in miceMechanisms

Nature MetabolismNov 16

Senescent cells promote tissue NAD⁺ decline during ageing via the activation of CD38⁺ macrophages

Experiments in animalsCellular senescence

Biochemical and Biophysical Research CommunicationsApr 8

The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD⁺ decline

Experiments in cellsCellular senescence