Tissue disorganization and loss of protein expression

1 paper mentions it1 finding

“increasing tissue disorganization and loss of protein expression appeared to correlate with progression to (pre)malignancy.”

Associations

Progression to endometrial premalignancy or malignancy

upin humans1

1 study

Tissue disorganization and loss of protein expression is associated with progression to endometrial premalignancy or malignancy in humans (Lynch syndrome).
“increasing tissue disorganization and loss of protein expression appeared to correlate with progression to (pre)malignancy.”
HumansLynch syndromeendometriumfemalesn = 32
Histopathological and immunohistochemical analyses do not indicate timing of prophylactic hysterectomy: a retrospective analysis of endometrial biopsies in Lynch syndrome carriers
Familial cancerOct 15, 2026

1 paper in 12 months

Familial CancerOct 16

Cohort study of 32 peopleLynch syndrome