TCR chain number

TCR chain number lowers the risk of mortality in humans (OR: TRA=0.74;p=0.0008, TRB=0.76;p=0.0018).

“higher numbers of TCR chains (OR: TRA=0.74;p=0.0008, TRB=0.76;p=0.0018) and TCR clonal diversity (OR: TRA=0.66; p < 0.0001, TRB=0.7; p < 0.0001) were significantly associated with reduced mortality”

Humans4-yearn = 3,758

The impact of T cell repertoire on mortality: Findings from the Health and Retirement Study

GSA 2025 abstract·31 Dec 2025