Tau PET binding

Female sex is associated with tau PET binding in humans (t1=6.67; t2=4.31 in lateral occipital).

“Elevated tracer uptake in females was present in 19 (Knight ADRC 1 ) and 12 (ADNI 2 ) regions, but most prominently in the lateral occipital”

Humanscognitively unimpaired participants with amyloid burden below pathological levelsbrainfemales

Age‐ and sex‐effects on tau PET binding in the absence of beta‐amyloid pathology

AAIC 2025 abstract·24 Dec 2025

Chronological age is associated with tau PET binding in humans (t1=9.40; t2=10.50 in putamen).

“Significant positive associations between tau PET binding and age occurred in 7 (Knight ADRC 1 ) and 13 (ADNI 2 ) regions, with the largest effects seen in the putamen”

Humanscognitively unimpaired participants with amyloid burden below pathological levelsbrain

Age‐ and sex‐effects on tau PET binding in the absence of beta‐amyloid pathology

AAIC 2025 abstract·24 Dec 2025