Systemic proteomic age gap

1. Systemic proteomic age gap is associated with walking speed in humans (β=0.02, 95% CI 0.01–0.03).

   “and slower walking speed (β=0.02, 95% CI 0.01-0.03, P=0.006, FDR=0.04)”

   HumansMultiple sclerosis

   Proteomic Age Acceleration in Multiple Sclerosis Precedes Symptom Onset and Associates with Severity

   medRxiv : the preprint server for health sciences·20 Apr 2026Preprint

1. Systemic proteomic age gap is associated with age-Related Multiple Sclerosis Severity Score in humans (β=0.14, 95% CI 0.05–0.24).

   “Higher systemic age gap was associated with greater global Age-Related Multiple Sclerosis Severity Score (β=0.14, 95% CI 0.05-0.24, P=0.005, FDR=0.03)”

   HumansMultiple sclerosis

   Proteomic Age Acceleration in Multiple Sclerosis Precedes Symptom Onset and Associates with Severity

   medRxiv : the preprint server for health sciences·20 Apr 2026Preprint

1. Multiple sclerosis is associated with systemic proteomic age gap in humans (β=2.2, 95% CI 1.2–3.2).

   “In the Johns Hopkins cohort, people with multiple sclerosis demonstrated acceleration of systemic (β=2.2, 95% CI 1.2-3.2, P<0.001, FDR<0.001)”

   HumansJohns Hopkins cohort; multiple sclerosis versus age-matched controls

   Proteomic Age Acceleration in Multiple Sclerosis Precedes Symptom Onset and Associates with Severity

   medRxiv : the preprint server for health sciences·20 Apr 2026Preprint

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