Brain proteomic age gap

1. Multiple sclerosis is associated with brain proteomic age gap in humans (β=2.4, 95% CI 1.2–3.7).

   “Proteomic age acceleration was evident prior to symptom onset [systemic: (β=1.0, 95% CI 0.4-1.7, P=0.002, FDR=0.02); brain: (β=2.4, 95% CI 1.2-3.7, P<0.001, FDR=0.002)]”

   HumansPre-symptomatic multiple sclerosisMedian lead time: 4.0 years

   Proteomic Age Acceleration in Multiple Sclerosis Precedes Symptom Onset and Associates with Severity

   medRxiv : the preprint server for health sciences·20 Apr 2026Preprint

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