Symbol digit substitution task

1. Symbol digit substitution task predicts dementia in humans (HR 3.22, 95% CI 2.39-4.33).

   “hazard regression and 95% CI for those with a decline of 1.5 SD or more in word list memory, TMT‐A, forward digit span, backward digit span, TMT‐B, and SDST were 1.77 (95% CI: 1.28‐2.44), 1.37 (95% CI: 0.96‐1.95), 1.91 (95% CI: 1.29‐2.81), 2.12 (95% CI: 1.49‐3.02), 2.41 (95% CI: 1.78‐3.25), and 3.22 (95% CI: 2.39‐4.33)”

   Humans5 yearsn = 2,441

   Predicting Dementia Onset with the Updated Cut‐off Points of the National Center for Geriatrics and Gerontology‐Functional Assessment Tool

   AAIC 2025 abstract·23 Dec 2025

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