Sperm epigenetic age
2 papers5 findings
- Humans1
- Animals1
Effects
1Standard semen characteristics
no changein humans1
1 study
Standard semen characteristics
no changein humans1
Sperm epigenetic age has no effect on standard semen characteristics in humans.
“SEA was not associated with standard semen characteristics in SEEDS and LIFE cohorts.”
Humansmultivariable linear regression adjusting for BMI and smoking statusmales
Current issues in molecular biology16 Feb 2024
Upstream
2mTOR signalling
upin mice1
1 study
mTOR signalling
upin mice1
mTOR signalling increases sperm epigenetic age in mice.
“shift in favor of mTOR complex one accelerates aging of the sperm DNA-methylome and results in a reproductive phenotype concordant with older age”
Animalsshift in favor of mTOR complex one in Sertoli cellssperm
Preprint3 Jan 2024
mTORC2 signalling
downin mice1
1 study
mTORC2 signalling
downin mice1
mTORC2 signalling decreases sperm epigenetic age in mice.
“Experiments with transgenic mice demonstrate that the shift of the balance in favor of mTOR complex two rejuvenates sperm DNA-methylome”
Animalsshift of the balance in favor of mTOR complex two in Sertoli cellssperm
Preprint3 Jan 2024
Associations
2Sperm head defects
upin humans1
1 study
Sperm head defects
upin humans1
Sperm epigenetic age is associated with sperm head defects in humans (p < 0.05).
“SEA was significantly associated with higher sperm head length and perimeter, the presence of pyriform and tapered sperm, and lower sperm elongation factor in the LIFE study (p < 0.05).”
HumansLIFE study, adjusting for BMI and smoking statusmales
Current issues in molecular biology16 Feb 2024
mTOR signalling
mixedin mice1
1 study
mTOR signalling
mixedin mice1
mTOR signalling is associated with sperm epigenetic age in mice.
“balance of mTOR complexes in Sertoli cells regulates the rate of sperm epigenetic aging”
Animalsin transgenic mice
Preprint3 Jan 2024