Skewed X chromosome inactivation

1. Skewed X chromosome inactivation is associated with myeloid lineage bias in humans.

   “XCI-skew is independent of traditional markers of biological ageing and is associated with a haematopoietic bias towards the myeloid lineage.”

   Humanswhole bloodfemalesn = 1,575

   Age acquired skewed X chromosome inactivation is associated with adverse health outcomes in humans

   eLife·Nov 22, 2022

1. Skewed X chromosome inactivation predicts cancer in humans.

   “In a prospective 10 year follow-up study, XCI-skew is predictive of future cancer incidence.”

   Humanswhole blood10 yearfemalesn = 1,575

   Age acquired skewed X chromosome inactivation is associated with adverse health outcomes in humans

   eLife·Nov 22, 2022

More on Cancer

1. Skewed X chromosome inactivation is associated with cardiovascular disease risk in humans.

   “XCI-skew is associated with an increased cardiovascular disease risk both cross-sectionally and within XCI-skew discordant twin pairs.”

   Humanswhole bloodfemalesn = 1,575

   Age acquired skewed X chromosome inactivation is associated with adverse health outcomes in humans

   eLife·Nov 22, 2022