Single-point insulin sensitivity estimator index
Biomarker1 paper1 finding
- Humans1
Associations
1Cardiovascular disease
downin humans1−22% lower risk
1 study
Cardiovascular disease
downin humans1−22% lower risk
Single-point insulin sensitivity estimator index lowers the risk of cardiovascular disease in humans (22% lower risk).
Humanshighest tertile of baseline SPISE index
Variations in Single-Point Insulin Sensitivity Estimator Index and the Risk of Cardiovascular Disease in Individuals With Cardiovascular-Kidney-Metabolic Syndrome Stages 0 to 3: A National Longitudinal Cohort Study · Journal of the American Heart Association · 24 Sep 2026