Simpson's clonality

1. Late-onset Alzheimer's disease is associated with Simpson's clonality in humans.

   “TCR sequence diversity measured as Simpson's clonality was lower among LOAD+MCI compared with non-LOAD, but these differences were not independent of age.”

   Humans

   Evidence for reduced somatic T-cell receptor sequence diversity profiles among Midwestern Amish in an aging cohort study

   medRxiv : the preprint server for health sciences·26 Jan 2026Preprint

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