Simplified frailty index

1. Simplified frailty index decreases cancer-specific survival in humans (p < 0.001, AUC 0.823).

   “Compared with patients with low sFI score, those with high sFI scores had significantly lower OS and CSS (p < 0.001)”

   Humansafter radical nephroureterectomyn = 333

   A simplified frailty index and nomogram to predict the postoperative complications and survival in older patients with upper urinary tract urothelial carcinoma

   Frontiers in oncology·Oct 11, 2023

1. Simplified frailty index decreases overall survival in humans (p < 0.001, AUC 0.815).

   “sFI score was an independent prognostic factor for OS and CSS, with AUC values of 0.815 and 0.823 for predicting 3-year OS and CSS, respectively”

   Humansafter radical nephroureterectomyn = 333

   A simplified frailty index and nomogram to predict the postoperative complications and survival in older patients with upper urinary tract urothelial carcinoma

   Frontiers in oncology·Oct 11, 2023

1. Simplified frailty index has no effect on cognitive function in humans (OR 1.5, 95%CI [0.96-2.3], p=0.07).

   “The sFI score was not associated with deficits in the Mini-Cog (OR 1.5, 95%CI [0.96-2.3], p=0.07).”

   Humansunderwent surgeryn = 334

   Evaluation of a commonly used tool: Does the 5-item frailty index predict phenotypic frailty?

   Archives of gerontology and geriatrics·Apr 11, 2023

1. Simplified frailty index predicts postoperative morbidity in humans (OR: 2.06, 95% CI: 1.27-3.34, p = .004).

   “In patients ≥ 80 years, morbidity was predicted by simplified Frailty Index (sFI) ≥ 2 (OR: 2.06, 95% CI: 1.27-3.34, p = .004)”

   Humansradical cystectomy30-dn = 424

   Radical cystectomy in patients aged < 80 years versus ≥ 80 years: analysis of preoperative geriatric assessment scores in predicting postoperative morbidity and mortality

   World journal of urology·Sep 30, 2024

2. Simplified frailty index predicts postoperative morbidity in humans (OR 2.59, 95% CI 1.84-3.63).

   “In multivariate regression, a Simplified Frailty Index was significantly associated with postoperative morbidity (Simplified Frailty Index ≥ 2: odds ratio = 2.59, 95% confidence interval [1.84-3.63], P < .0001).”

   Humansbowel resection for Crohn's disease

   Frailty is a stronger predictor than age for postoperative morbidity in Crohn's disease

   Surgery·May 28, 2021

1. Simplified frailty index predicts infection in humans (P = 0.012).

   “For early infections, MRP was not predictive (P = 0.237) whereas FI was (P = 0.012)”

   Humansin patients with newly diagnosed multiple myeloma

   Impact of frailty tools on outcomes in myeloma: MRP and simplified index predict survival but differ in infection risk stratification

   Hematology (Amsterdam, Netherlands)·Mar 9, 2026

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1. Simplified frailty index raises the risk of mortality in humans (HR 2.12).

   “The frail groups by MRP and the Simplified FI had significantly shorter OS (36 vs. 75 months and 38 vs. 76 months) and PFS (11 vs. 21 months and 11 vs. 23 months; P < 0.001) with increased mortality risk (HR: 2.51 and 2.12).”

   Humansin patients with newly diagnosed multiple myeloma

   Impact of frailty tools on outcomes in myeloma: MRP and simplified index predict survival but differ in infection risk stratification

   Hematology (Amsterdam, Netherlands)·Mar 9, 2026

1. Simplified frailty index predicts grade 3-4 non-hematologic toxicity in humans (HR 2.49, 95% CI 1.09 to 5.95).

   “frail patients defined by the simplified frailty index (hazard ratio [HR], 2.49; 95% confidence interval [CI], 1.09 to 5.95; p=0.030)”

   Human trialnewly diagnosed multiple myeloman = 100

   Validating the Korean Geriatric Assessment Tool in Elderly Multiple Myeloma Patients: A Multicenter Study

   Cancer research and treatment·Feb 21, 2025

1. Simplified frailty index predicts postoperative complications in humans (AUC= 0.756).

   “sFI significantly influenced the incidence of postoperative complications in older patients (AUC= 0.756)”

   Humansafter radical nephroureterectomyn = 333

   A simplified frailty index and nomogram to predict the postoperative complications and survival in older patients with upper urinary tract urothelial carcinoma

   Frontiers in oncology·Oct 11, 2023

1. Simplified frailty index is associated with abnormal gait speed in humans (OR 1.9, 95%CI 1.2-3.0, p<0.01).

   “abnormal gait speed (OR 1.9, 95%CI 1.2-3.0, p<0.01).”

   Humansunderwent surgeryEach 1-point increase in sFI scoren = 334

   Evaluation of a commonly used tool: Does the 5-item frailty index predict phenotypic frailty?

   Archives of gerontology and geriatrics·Apr 11, 2023

1. Simplified frailty index is associated with activities of daily living deficit in humans (OR 2.3, 95%CI [1.5-3.8], p<0.0001).

   “Each 1-point increase in sFI score was associated with increased odds of ADL deficit (OR 2.3, 95%CI [1.5-3.8], p<0.0001)”

   Humansunderwent surgeryEach 1-point increase in sFI scoren = 334

   Evaluation of a commonly used tool: Does the 5-item frailty index predict phenotypic frailty?

   Archives of gerontology and geriatrics·Apr 11, 2023

1. Simplified frailty index is associated with Sinai Abbreviated Geriatric Evaluation in humans (r=-0.24, p<0.0001).

   “SAGE and sFI scores were significantly associated, with a modest inverse relationship (r=-0.24, p<0.0001).”

   Humansunderwent surgeryn = 334

   Evaluation of a commonly used tool: Does the 5-item frailty index predict phenotypic frailty?

   Archives of gerontology and geriatrics·Apr 11, 2023

More on Sinai Abbreviated Geriatric Evaluation