Senescent-like CD8+ T cells

1 paper2 findings

Humans1

Effects

1

Cell killing (cytotoxicity)

downin human cells1

1 study

Senescent-like CD8+ T cells impair cell killing (cytotoxicity) in human cells.
“senescent-like bone marrow CD8+ T cells were impaired in killing autologous AML blasts”
Cellsautologous AML blastsbone marrow
Immune dysfunction signatures predict outcomes and define checkpoint blockade-unresponsive microenvironments in acute myeloid leukemia
The Journal of clinical investigationSep 14, 2022

More on Cell killing (cytotoxicity)

Associations

1

Lifespan

downin humans1

1 study

Senescent-like CD8+ T cells are associated with lifespan in humans.
“their proportion negatively correlated with overall survival (OS)”
Humansin acute myeloid leukemiabone marrow
Immune dysfunction signatures predict outcomes and define checkpoint blockade-unresponsive microenvironments in acute myeloid leukemia
The Journal of clinical investigationSep 14, 2022

Latest

The Journal of Clinical InvestigationSep 14

Immune dysfunction signatures predict outcomes and define checkpoint blockade-unresponsive microenvironments in acute myeloid leukemia

Cohort study of 1,896 peopleAcute myeloid leukemia

Nature ImmunologyApr 2

Sestrins induce natural killer function in senescent-like CD8⁺ T cells

Experiments in cellsMechanisms