What does the research say about resting plasma irisin?

Resting plasma irisin

There is 1 paper on resting plasma irisin in aging research: 1 observational study in people. The newest story, Nov 12, 2026: “Resting blood irisin levels were lower in older adults”.

Biomarker

1 paper studies it2 findings

1 new paper in 30 daysSee all 1 papers on resting plasma irisin

“Multivariable regression analyses demonstrated a significant inverse association between chronological age and RPI”

Resting plasma irisin shows lower levels in older adults independently of muscle mass and physical activity and is not associated with cognitive performanceScientific reports2026doi:10.1038/s41598-026-80037-8

Humans1

Effects

Cognitive function

no changein humans1

1 study

Resting plasma irisin was not clearly linked with cognitive function In either age group, including adjustment for body composition and physical activity.
“RPI was not associated with any cognitive outcome in either age group, even after adjustment for body composition and physical activity.”
HumansIn either age group, including adjustment for body composition and physical activityBoths
Resting blood irisin levels were lower in older adults
Scientific reportsNov 12, 2026

Associations

Chronological age

downin humans1

1 study

Chronological age is associated with resting plasma irisin in humans (Independent of sex, body composition, physical activity, and basal metabolic rate) (β = −4.57 pg/mL/year; 95% CI −5.90 to −3.24).
“Multivariable regression analyses demonstrated a significant inverse association between chronological age and RPI”
HumansIndependent of sex, body composition, physical activity, and basal metabolic ratePlasmaBoths
Resting blood irisin levels were lower in older adults
Scientific reportsNov 12, 2026

Latest

1 paper in 12 months

Scientific ReportsNov 12

Resting blood irisin levels were lower in older adults

Each additional year of age was associated with 4.57 picograms per milliliter less resting plasma irisin, after accounting for body composition and physical activity.Each additional year of age was associated with 4.57 picograms per milliliter less resting plasma irisin, after accounting for body composition and physical activity.

Cross-sectional studyMechanisms

Paper