What does the research say about Relative occupancy of a commitment-associated OPC state?

Relative occupancy of a commitment-associated OPC state

There is 1 paper on relative occupancy of a commitment-associated OPC state in aging research: 1 observational study in people. The newest story, Oct 31, 2026: “Age-linked gene shifts span human brain precursor cell states”.

Biomarker

1 paper studies it1 finding

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“The relative occupancy of a commitment-associated OPC state declined with age in both donor sources after adjustment for sampled OPC depth”

Within-state transcriptional remodelling predominates in a 41-gene ageing programme of human prefrontal OPCsNeurobiology of disease2026doi:10.1016/j.nbd.2026.107670

Humans1

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Age

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1 study

Age is associated with relative occupancy of a commitment-associated OPC state in humans.
“The relative occupancy of a commitment-associated OPC state declined with age in both donor sources after adjustment for sampled OPC depth”
HumansBoth donor sources; adjusted for sampled OPC depth; sampled nuclei rather than absolute tissue abundanceoligodendrocyte precursor cell
Age-linked gene shifts span human brain precursor cell states
Neurobiology of diseaseOct 30, 2026

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1 paper in 12 months

Neurobiology of DiseaseOct 31

Age-linked gene shifts span human brain precursor cell states

Within-group changes accounted for 98.8–99.5% of a 41-gene pattern’s adjusted age-related difference, versus 0.8–1.2% from changes in group proportions.Within-group changes accounted for 98.8–99.5% of a 41-gene pattern’s adjusted age-related difference, versus 0.8–1.2% from changes in group proportions.

Cross-sectional · 349 peopleMechanisms

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Relative occupancy of a commitment-associated OPC state

Associations

Latest

Age-linked gene shifts span human brain precursor cell states

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