41-gene OPC aging program

within-state transcriptional remodeling is linked with 41-gene OPC aging program in humans (Adjusted cell-mean contrast under the primary clustering configuration) (98.8-99.5% of adjusted cell-mean contrast; composition accounted for 0.8-1.2%).

“formal decomposition showed that within-state change accounted for 98.8-99.5% of the programme's adjusted cell-mean contrast”

HumansAdjusted cell-mean contrast under the primary clustering configurationoligodendrocyte precursor celln = 349

Age-linked gene shifts span human brain precursor cell states

Neurobiology of disease·Oct 30, 2026