Neurobiology of Disease
Age-linked gene shifts span human brain precursor cell states
Within-group changes accounted for 98.8–99.5% of a 41-gene pattern’s adjusted age-related difference, versus 0.8–1.2% from changes in group proportions.Within-group changes accounted for 98.8–99.5% of a 41-gene pattern’s adjusted age-related difference, versus 0.8–1.2% from changes in group proportions.
Cross-sectional · 349 peopleMechanisms
Who was studied349 human prefrontal cortex donors
What changedWithin-state gene changes accounted for 98.8-99.5% of the adjusted age-related difference; changes in cell-state proportions contributed little
The catchThe breakdown omits age-related gene changes outside the 41-gene program