What does the research say about rare coding variants?

Rare coding variants

There is 1 paper on rare coding variants in aging research: 1 observational study in people. The newest story, Nov 12, 2026: “Rare DNA variants more common in people with exceptional memory”.

Biomarker

1 paper studies it13 more mention it1 finding

2 new papers in 30 daysSee all 14 papers on rare coding variants

“a rare variant allele frequency analysis identified 114 significant rare coding variants enriched in cognitive superagers.”

Enrichment of Rare Exonic Variants in Cognitive Superagers from Centenarian FamiliesmedRxiv2026doi:10.64898/2026.11.10.26365445

Humans1

Associations

Cognitive superager status

upin humans1

1 study

Rare coding variants are associated with cognitive superager status in humans (Compared with average-cognition controls and the gnomAD population reference database) (114 significant rare coding variants enriched).
“a rare variant allele frequency analysis identified 114 significant rare coding variants enriched in cognitive superagers.”
HumansCompared with average-cognition controls and the gnomAD population reference databasen = 136
Rare DNA variants more common in people with exceptional memory
medRxivNov 12, 2026Preprint

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2 papers in 12 months

medRxivNov 12

Rare DNA variants more common in people with exceptional memory

The genetic comparison identified 114 rare protein-coding variants enriched in superagers compared with average-cognition controls and a population reference database.The genetic comparison identified 114 rare protein-coding variants enriched in superagers compared with average-cognition controls and a population reference database.

Preprint: genetic association · 136 peoplePopulations