ESC Congress 2026 Abstract
Heart electrical fibers remodel and fragment with age in sheep
Comparing heart tissue from sheep identified 407 genes enriched in electrical conduction fibers relative to surrounding muscle and sheath tissue, with bundles fragmenting…Comparing heart tissue from sheep identified 407 genes enriched in electrical conduction fibers relative to surrounding muscle and sheath tissue, with bundles fragmenting in older hearts.
Cross-sectional studyExtracellular matrix remodeling
Who was studiedYoung and mature sheep, against young sheep
What changedOlder sheep hearts had more collagen partitioning and fragmentation of electrical fiber bundles than young hearts
The catchFiber changes within individual sheep over time were not measured