Protein 4.1a/4.1b ratio

Sex has no effect on protein 4.1a/4.1b ratio in humans.

“Ratios did not differ significantly between females and males (P=0.246)”

HumansComplete blood count parameters within laboratory reference intervalsred blood celln = 114

A Practical Assay for Assessing Mean Red Blood Cell Age Using the Protein 4.1a/4.1b Ratio

bioRxiv·9 Oct 2026Preprint

Chronological age is associated with protein 4.1a/4.1b ratio in humans (Spearman correlation 0.26).

“The ratio showed modest positive correlations with chronological age in females (Spearman p=0.26, P=0.047) and males (p=0.33, P=0.015)”

HumansComplete blood count parameters within laboratory reference intervalsred blood cellfemales

A Practical Assay for Assessing Mean Red Blood Cell Age Using the Protein 4.1a/4.1b Ratio

bioRxiv·9 Oct 2026Preprint