Proinsulin-to-insulin ratio

1. Inflammation increases proinsulin-to-insulin ratio in mice.

   “accompanied by an increased proinsulin-to-insulin ratio in circulation, indicative of impaired proinsulin processing”

   Animalsin aging micepancreatic islets

   IL-1 and IL-6 Impair Proinsulin Maturation in Aging Mice via Downregulation of Prohormone Convertases

   ADA Scientific Sessions 2025 abstract·13 Jun 2025

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