proBNPage

1. Coenzyme Q10 + selenium has no effect on proBNPage in humans.

   “Partly because of dropouts and inadequate treatment intake, groups A and C showed non-significant differences in the primary and secondary variables.”

   Human trialGroup A versus placebo; dropouts and inadequate treatment intakecoenzyme Q10 100 mg bid + selenium 100 mcg2 years

   The proBNPage reduction (PBAR) trial-results of a randomized, double blind, placebo-controlled, pilot study to fine tune an NT-proBNP-based method to assess the effect of anti-aging treatments

   GeroScience·8 Sep 2025

More on Coenzyme Q10 + selenium

1. elapsed time is associated with proBNPage in humans (+2.5 years over 2 years).

   “after 2 years proBNPage increased by 2.5 years (P = 0.01), particularly in subjects over 70 (+ 3.0 years, P = 0.009).”

   Human trialPooled coenzyme Q10 plus selenium and placebo groups2 years

   The proBNPage reduction (PBAR) trial-results of a randomized, double blind, placebo-controlled, pilot study to fine tune an NT-proBNP-based method to assess the effect of anti-aging treatments

   GeroScience·8 Sep 2025

1. proBNPage predicts mortality in humans (HR 7.9, 95% CI 3.6-17.5).

   “The hazard ratio of all-cause mortality for the fifth quintile of proBNP age (≥ 85 years) compared with the first quintile (< 61 years) was 7.9 (95% CI 3.6-17.5).”

   Humansfifth quintile (≥ 85 years) compared with first quintile (< 61 years)7 yearsn = 1,079

   N-terminal pro B-type natriuretic peptide (NT-proBNP): a possible surrogate of biological age in the elderly people

   GeroScience·11 Aug 2020