ProAL50

1. ProAL50 predicts mortality in humans.

   “In prospective analyses, ProAL50 showed associations with incident chronic disease, including type 2 diabetes, ischemic heart disease, chronic lung disease, chronic liver disease, chronic kidney disease, overall cancer, and all-cause and cause-specific mortality”

   Humansprospective analyses

   A Circulating Proteomic Signature of Allostatic Load Is Associated with Multisystem Disease and Mortality

   Proteomes·Sep 10, 2026

1. ProAL50 is associated with allostatic load in humans (r = 0.72).

   “ProAL50 correlated strongly with traditional AL in the held-out test set (r = 0.72)”

   Humansheld-out test set

   A Circulating Proteomic Signature of Allostatic Load Is Associated with Multisystem Disease and Mortality

   Proteomes·Sep 10, 2026

More on Allostatic load

1. ProAL50 raises the risk of chronic liver disease in humans (HR = 2.12, 95% CI 1.96-2.29).

   “chronic liver disease (HR = 2.12, 95% CI 1.96-2.29).”

   Humans

   A Circulating Proteomic Signature of Allostatic Load Is Associated with Multisystem Disease and Mortality

   Proteomes·Sep 10, 2026

More on Chronic liver disease

1. ProAL50 raises the risk of type 2 diabetes in humans (HR per SD = 2.72, 95% CI 2.61-2.84).

   “Representative associations included incident type 2 diabetes (HR per SD = 2.72, 95% CI 2.61-2.84)”

   Humans

   A Circulating Proteomic Signature of Allostatic Load Is Associated with Multisystem Disease and Mortality

   Proteomes·Sep 10, 2026

More on Type 2 diabetes

1. ProAL50 is associated with lipid metabolic and immune-inflammatory pathways in humans.

   “Functional enrichment analyses revealed that ProAL50 proteins cluster within lipid metabolic and immune-inflammatory pathways.”

   HumansFunctional enrichment analysisplasma

   A Circulating Proteomic Signature of Allostatic Load Predicts Multisystem Disease and Mortality

   Research square·Apr 16, 2026Preprint

1. ProAL50 predicts all-cause and cause-specific mortality in humans.

   “and with all-cause and cause-specific mortality.”

   HumansCompared with traditional allostatic load

   A Circulating Proteomic Signature of Allostatic Load Predicts Multisystem Disease and Mortality

   Research square·Apr 16, 2026Preprint

1. ProAL50 predicts incident chronic disease in humans.

   “ProAL50 consistently demonstrated stronger associations with incident chronic diseases, including all cancers, type 2 diabetes, ischemic heart disease, chronic lung disease, and chronic kidney disease”

   HumansCompared with traditional allostatic load

   A Circulating Proteomic Signature of Allostatic Load Predicts Multisystem Disease and Mortality

   Research square·Apr 16, 2026Preprint

More on Incident chronic disease