Nature Medicine
Hormone therapy responses varied with women’s microbiomes
In a six-month trial of 356 perimenopausal women, starting vaginal and gut microbial communities were linked to differences in hormone therapy responses.In a six-month trial of 356 perimenopausal women, starting vaginal and gut microbial communities were linked to differences in hormone therapy responses.
Cohort · 327 peopleGut and microbiome
Who was studied327 perimenopausal women, 6 months, against women with P. copri-dominated microbiomes
What changedAfter hormone therapy, 4-week symptom remission was higher with P. vulgatus-dominated microbiomes: 38.7% versus 23.5% with P. copri-dominated microbiomes
The catchSymptom improvements could reflect temporal trends, placebo effects, or regression to the mean