Presynaptic Apoe abundance

Age is associated with presynaptic Apoe abundance in mice.

“identified apolipoprotein E (APOE) as an abundant presynaptic protein further enriched in aged female samples.”

Animalswild-type C57BL/6J micesynaptic vesiclesfemales

APOE is a presynaptic protein that accumulates with age and modulates neurotransmitter release

bioRxiv : the preprint server for biology·21 Apr 2026Preprint