Predicted 10-year ASCVD risk

1 paper4 findings

A human study associates total PCB exposure with higher predicted 10-year ASCVD risk cross-sectionally, and persistent high PCB-118 exposure with a greater longitudinal increase and transition to predicted high-risk status. Its analysis identifies 8-iso-prostaglandin F2α as a mediator of the association between PCBs and predicted risk.

Humans1

Upstream

1

8-iso-prostaglandin F2α

mediatesin humans1

1 study

8-iso-prostaglandin F2α mediates predicted 10-year ASCVD risk in humans (3.29 % to 11.62 %).
Humansassociation between PCBs and predicted ASCVD risk
Cross-sectional and longitudinal relationships between exposure to polychlorinated biphenyls and predicted 10-year atherosclerotic cardiovascular disease risk: Integrated epidemiological and bioinformatics analysis
Environment international30 Aug 2026

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Associations

2

PCB-118

upin humans1RR 1.432

1 study

PCB-118 raises the risk of predicted 10-year ASCVD risk in humans (RR = 1.432, 95 % CI: 1.012-2.027).
Humanslongitudinal transition to predicted high-risk status
Cross-sectional and longitudinal relationships between exposure to polychlorinated biphenyls and predicted 10-year atherosclerotic cardiovascular disease risk: Integrated epidemiological and bioinformatics analysis
Environment international30 Aug 2026
PCB-118 is associated with predicted 10-year ASCVD risk in humans (0.510 percentage-point greater increase (95 % CI: 0.023-0.996)).
Humanslongitudinally, persistent high PCB-118 exposure vs persistent low
Cross-sectional and longitudinal relationships between exposure to polychlorinated biphenyls and predicted 10-year atherosclerotic cardiovascular disease risk: Integrated epidemiological and bioinformatics analysis
Environment international30 Aug 2026

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Polychlorinated biphenyls

upin humans1

1 study

Polychlorinated biphenyls are associated with predicted 10-year ASCVD risk in humans (1.829-percentage-point higher predicted 10-year ASCVD risk).
Humanscross-sectional analysis, ln-transformed ΣPCB
Cross-sectional and longitudinal relationships between exposure to polychlorinated biphenyls and predicted 10-year atherosclerotic cardiovascular disease risk: Integrated epidemiological and bioinformatics analysis
Environment international30 Aug 2026

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