2 findings
“Patients with positively selected CH during treatment had the shortest progression-free and overall survival”
Interventions
1Cytotoxic cancer therapy
upin humans1
1 study
Cytotoxic cancer therapy
upin humans1
Cytotoxic cancer therapy is linked with positively selected clonal hematopoiesis in humans (through dose-dependent therapeutic bottlenecks).
“Positively selected CH that expanded through dose-dependent therapeutic bottlenecks”
Humansthrough dose-dependent therapeutic bottlenecks
Breast cancer therapy linked to shifts in mutated blood cells
The Journal of clinical investigation
Associations
1Progression-free survival
downin humans1
1 study
Progression-free survival
downin humans1
Positively selected clonal hematopoiesis predicts progression-free survival in humans (compared with patients with unchanging or negatively selected CH, across all therapies).
“Patients with positively selected CH during treatment had the shortest progression-free and overall survival”
Humanscompared with patients with unchanging or negatively selected CH, across all therapies
Breast cancer therapy linked to shifts in mutated blood cells
The Journal of clinical investigation